Neurapheresis Cerebrospinal Fluid Management System

Fast, efficient removal of toxins from cerebrospinal fluid.

Neurapheresis CSF Management System is designed to provide a safe, device-based alternative for treating debilitating and life-threatening diseases that involve contaminants in the cerebrospinal fluid.

Blood in the spinal fluid is problematic for aneurysmal Subarachnoid Hemorrhage (aSAH) patients.

aSAH is a catastrophic neurological condition occurring after the rupture of a cerebral aneurysm. The presence of blood in the spinal fluid increases the risk of complications such as delayed neurological deficits, edema, hydrocephalus and stroke. Without removal of blood from the central nervous system, aSAH patients have 3.7x greater risk of stroke and 2.6x greater risk of requiring endovascular procedures1.

>30KUS cases annually 2Mcases worldwide 15%mortality 50%morbidity

1 Klimo P et al. Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage, J Neurosurg. 2004 Feb;100(2): 215-24.

Standard of Care

The standard of care doesn’t address blood left behind in CSF.

The standard of care effectively manages the primary injury by clipping or coiling the aneurysm, but doesn’t manage the resulting blood. This contributes to high morbidity and mortality rates.

  • Following securement, patients typically stay in hospital for at least 14 days to monitor for secondary complications
  • Red blood cells in subarachnoid space break down over several days, releasing hemoglobin and other toxins1

 

1 Blackburn SL, Grande AW, Swisher CB, Hauck EF, Jagadeesan B, Provencio JJ. Prospective Trial of Cerebrospinal Fluid Filtration After Aneurysmal Subarachnoid Hemorrhage via Lumbar Catheter (PILLAR). Stroke. 2019;50(9):2558-2561.

Patient Benefits

Removal of blood from CSF has been shown to be beneficial.

Rapid and early removal of red blood cells and blood byproducts from the cerebrospinal fluid may improve poor outcomes associated with aSAH.

aSAH patient benefits:

  • 34% less likely to suffer delayed ischemic neurologic deficit1-2
  • Less time in the Neuro ICU1-2
  • 2x more likely to be discharged home1-2

 

1 Klimo P et al. Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage, J Neurosurg. 2004 Feb;100(2): 215-24.
2 Al-Tamimi YZ et al. Lumbar drainage of cerebrospinal fluid after aneurysmal subarachnoid hemorrhage: a prospective, randomized, controlled trial (LUMAS). Stroke. 2012 Mar;43(3):677-82.

Neurapheresis CSF Management System

Designed to be a simple, safe approach for removing blood from the CSF.

  • Uses standard lumbar access
  • Rapid removal of blood and breakdown products
  • Fast clearance of contaminants
  • Minimally invasive for patient
  • Personalized treatment based on hemorrhage burden
  • Early intervention to reduce morbidity

How Neurapheresis CSF Management System works.

  • Neurapheresis starts shortly after aneurysm securement
  • Dual lumen catheter is placed in the lumbar spine
  • Therapy efficiently separates blood from CSF
  • System rapidly removes blood and other toxins as waste

Clinical Investigation

The PILLAR trial evaluated the safety and feasability of Neurapheresis™ CSF Management System in aSAH.

  • Studied the efficacy of rapid removal of blood and blood breakdown products from CSF after securement of a ruptured aneurysm
  • PILLAR trial complete, results published
  • PILLAR XT extension trial complete, data analysis underway
See Full PILLAR Trial Results

 

Research supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R44NS110247

Blackburn SL, Grande AW, Swisher CB, Hauck EF, Jagadeesan B, Provencio JJ. Prospective Trial of Cerebrospinal Fluid Filtration After Aneurysmal Subarachnoid Hemorrhage via Lumbar Catheter (PILLAR). Stroke. 2019 Sep;50(9):2558-2561.

Interested in learning more about Neurapheresis? Contact us.

Call 651-917-4060 or email neuro@minnetronixmedical.com